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US 10,822,321 B2Granted
Processes and intermediates for the preparations of isomer free prostaglandins
AssigneeChirogate International Inc.
InventorsShih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
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Abstract
Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
Claims1
Latanoprost containing a non-detectable level of 5,6-trans isomer and 15β-isomer as determined by HPLC method, the limit of detection of HPLC method being more than 0.02%.
Dependencies are inferred from the claim text.