US 10,821,375 B2 · Continuous production of particles

Abstract

The present invention discloses a method to continuously manufacture micro- and/or nanoparticles of single component particles or multi-component particles such as particulate amorphous solid dispersions or particulate co-crystals. The continuous method comprises the steps of 1. preparing a first solution comprising at least one component and at least one solvent and a second solution comprising at least one anti-solvent of the at least one component comprised in the first solution, 2. mixing said first solution and said second solution by means of microfluidization to produce a suspension by precipitation or co-precipitation, 3. feeding said suspension to a filtration system to obtain a concentrate stream, 4. feeding said concentrate stream to a spray dryer, 5. atomizing said concentrate stream using at least one atomization nozzle, 6. drying said atomized concentrate stream to obtain particles, and 7. collecting said particles. Single component particles or multi-component particles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compositions are also disclosed.

Claims23

Dependent claims

A method of continuously manufacturing single component particles or multi-component particles, which method comprises the steps of:

preparing a first solution comprising at least one component and at least one solvent, and a second solution comprising at least one anti-solvent of the at least one component comprised in the first solution, wherein the second solution further comprises (1) at least one API, (2) at least one excipient, or (3) a combination of at least one API and at least one excipient;
continuously feeding said first solution and said second solution to at least one microreactor having a reaction chamber to obtain a first suspension containing particles and the substances in the two solutions by precipitation or co-precipitation of the substances in the two solutions;
continuously feeding said first suspension to a filtration system to obtain a concentrate stream, wherein the concentrate stream is a second suspension containing the particles and the substances in the two solutions;
continuously feeding said concentrate stream directly to a spray dryer;
atomizing said concentrate stream using at least one atomization nozzle;
drying said atomized concentrate stream to obtain the particles;
and
collecting said particles.

5 more elements

Dependencies are inferred from the claim text.

Continuous production of particles

Life of this patent

Continuous production of particles

Life of this patent

Abstract

Claims23