Labelled carboxylic acids and their uses in molecular imaging
AssigneeCancer Research Technologies Limited
InventorsEric O. Aboagye, Lisa Iddon, Federica Pisaneschi, Timothy H. Witney
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Abstract
The present invention pertains generally to the field of imaging compounds, and more specifically to certain 2,2-dialkyl radionuclide-labelled carboxylic acids suitable for PET, SPECT and/or DNP imaging. Also described are used of such compounds in the imaging of inter alia, cancer tumours, metastasis, Alzheimer's disease and multiple sclerosis.
Claims27
A composition comprising a tracer, wherein the tracer is a labelled carboxylic acid or the corresponding carboxylate of Formula (I)
- wherein
- CL is selected from [13C]carbon or [11C]carbon;
- n is 1, 2, or 3;
- R1 and R2 are independently C1-4-alkyl;
- R3 and R4 are independently H or F;
- and
- R5 is F, Cl, Br, I, or NH2.
A composition comprising a tracer, wherein the tracer is a labelled carboxylic acid or the corresponding carboxylate of Formula (I)
- wherein
- CL is selected from [13C]carbon, [12C]carbon, or [11C]carbon;
- n is 1, 2, or 3;
- R1 and R2 are independently C1-4-alkyl;
- R3 and R4 are independently H or F;
- and
- Q is selected from [13C] and [15N].
Dependencies are inferred from the claim text.