Polycyclic compounds and uses thereof

A method of treating fibrosis or pulmonary arterial hypertension comprising, administering to a subject in need thereof a therapeutically effective amount of a compound represented by structural Formula (I):

• or a salt thereof, wherein:
• represents an optional double bond;
• R1 is selected from hydrogen;
• and C1-C3 alkyl, C3-C5 cycloalkyl, C2-4 alkenyl, C3-C5 cycloalkenyl, C2-4 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
• R2 is selected from C1-C3 haloalkyl and C3-C5 cycloalkyl, wherein C3-C5 cycloalkyl is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
• R3 is selected from halogen, C1-C3 alkyl, C1-C3 haloalkyl, —OR10, —SR10, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, and —CN;
• R4 is absent or selected from hydrogen and OR10, wherein R4 is absent when is a double bond and R4 is selected from hydrogen and OR10 when is a single bond;
• R5 is selected from C1-C3 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN, wherein when R2 is selected from C1 haloalkyl and is a double bond, R5 is C1-C3 alkyl optionally substituted with one or more substituents independently selected from —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
• R6 is CH2CF3;
• R7 is selected from C1-C3 alkyl, C2-4 alkenyl, and C2-4 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
• R10 is independently selected at each occurrence from hydrogen;
• and C1-C3 alkyl optionally substituted with one or more substituents independently selected from halogen, —OH, —OCH3, —CF3, —SH, —NH2, —NO2, and —CN;
• and
• n is selected from 0, 1, 2, and 3.