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US 10,815,178 B2Granted
Intermolecular reaction of propargyl ethers with dimethylfuran in the presence of gold(I) complexes
AssigneeDsm IP Assets B.V.
InventorsUlla Letinois, Stephan Ackermann, Jonathan Alan Medlock, Hajo Lehmann
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Abstract
The present invention relates to a method of preparing ortho substituted phenols from 2,5-dimethylfuran and propargyl ethers in the presence of a gold(I) complex. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of said ortho substituted phenols.
Claims12
A process which comprises:
- (i) producing a compound of formula (I):
- wherein R1 represents a C1-10-alkyl group or a C4-7-cycloalkyl group by reacting in the presence of a gold(I) complex a compound of formula (II):
- with compound of formula (III):
- (ii) reducing the compound of formula (I) by a reducing agent in the presence of a heterogeneous metal catalyst to yield a compound of formula (A):
- wherein the metal is selected from the group consisting of Ni, Fe, Ir, Pd, Pt, Rh and Ru.
2 more elements
Dependencies are inferred from the claim text.