Papillomavirus pseudoviruses for detection and therapy of tumors
AssigneeThe USA, as represented by the Secretary, Dept. of Health and Human Services
InventorsJeffrey Roberts, Douglas R. Lowy, John T. Schiller
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Abstract
Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (VLP).
Claims15
A method comprising administering to a melanoma in a subject a papilloma pseudovirus that comprises a fluorescent dye, and exposing the fluorescent dye in the melanoma in the subject to an excitation wavelength of light.
A method comprising administering to a melanoma in a subject a papilloma virus-like particle (VLP) that comprises a fluorescent dye, and exposing the fluorescent dye in the melanoma in the subject to an excitation wavelength of light.
A method for detecting the presence of melanoma cells bound to a papilloma pseudovirus or papilloma VLP comprising:
- identifying a subject having or suspected of having melanoma cells;
- administering to the subject a detectable amount of a papilloma pseudovirus or a papilloma VLP that comprises a fluorescent dye;
- and
- detecting the presence of melanoma cells bound to the papilloma pseudovirus or papilloma VLP that comprises a fluorescent dye.
Dependencies are inferred from the claim text.