Composition of oily, pungent and odoriferous substances and a process of preparation thereof

A composition suitable for delayed, extended and sustained release, comprising:

• a spheroidal nutrient core including an oily, pungent, and odoriferous active substance, a cellulose containing polymer, one or more of sugar and starch and an excipient,
• wherein the oily, pungent, and odoriferous active substance is capsicum oleoresin and has a pungency rating of about 50,000 to 1,800,000 Scoville units,
• wherein the cellulose containing polymer is at least one selected from the group consisting of microcrystalline cellulose, colloidal grades carboxymethyl cellulose sodium, and hydroxypropyl methyl cellulose,
• wherein the sugar is at least one selected from the group consisting of mannitol, sucrose, xylitol, sorbitol, maltitol, lactitol, and isomalt,
• wherein the excipient includes a binder, wherein the binder is at least one selected from the group consisting of starch, pregelatinized starch, polyvinyl pyrrolidone (PVP), copovidone, gum acacia, xanthan gum, gum tragacanth, hydroxypropylmethyl cellulose (HPMC) and a salt thereof, hydroxypropyl cellulose (HPC) and a salt thereof, and carboxymethyl cellulose (CMC) and a salt thereof,
• the active substance, the at least one cellulose containing polymer, and the excipient being formed as a matrix, where the active substance is entrapped by the at least one cellulose containing polymer, so as to reduce or conceal a pungency and/or odor of the active substance and to provide delayed and then extended and sustained release of the active substance upon dissolution, where entrapment of the active substance is obtained by extrusion spheronization,
• the matrix including the active substance being uniformly mixed with the at least one cellulose containing polymer,
• the at least one cellulose containing polymer having a higher viscosity than that of the binder;
• and
• an outer enteric polymeric coating that coats the spheroidal nutrient core, the outer enteric polymeric coating to facilitate delayed and gradual release of the active substance, and the outer enteric polymeric coating being different from the at least one cellulose containing polymer,
• wherein the outer enteric polymeric coating is at least one selected from the group consisting of hydroxypropyl methyl cellulose acetate phthalate, hydroxypropyl methyl cellulose phthalate, methacrylate, phthalate methyl acrylate-methacrylic acid copolymer, cellulose acetate succinate, polyvinyl acetate phthalate, and a shellac dispersion containing polymer, and
• wherein the active substance is configured within the composition to be released at a rate of not more than 1% up to 2 hours, more than 75% in 4 hours, more than 90% up to 6 hours.