Cardiac valve repair system and methods of use

A system comprising:

• a catheter comprising a lumen, a proximal end, and a distal end;
• a handle connected to the catheter at the proximal end of the catheter;
• an anchor, wherein the anchor is transitionable between a straightened configuration, which can be disposed within the lumen for transvascular delivery through an opening in a blood vessel to a cardiac valve of a heart, and a deployed configuration comprising at least two turns;
• a replacement valve, wherein the replacement valve comprises an expandable frame and a valve body, wherein the valve body comprises multiple pieces of animal tissue sewn or bonded together to form replacement leaflets that can open to allow blood flow therethrough and close to prevent blood flow therethrough;
• wherein the replacement valve can transition from a collapsed configuration, for transvascular delivery through the opening in the blood vessel to the cardiac valve, to an expanded configuration;
• wherein the anchor can be transvascularly delivered through the lumen of the catheter to the cardiac valve such that at least one of the at least two turns encircles leaflets of the cardiac valve, and the replacement valve is configured such that the replacement valve can be transvascularly delivered to the cardiac valve in the collapsed configuration and expanded to the expanded configuration inside the anchor and thereby secure the replacement valve and the anchor at the cardiac valve;
• and
• wherein the expandable frame comprises a stent comprising a plurality of woven wires.

A system comprising:

• a first catheter comprising a first lumen;
• a handle connected to the first catheter;
• an anchor, wherein the anchor is transitionable between a straightened configuration, which can be disposed within the first lumen for transvascular delivery through an opening in a femoral vein to a cardiac valve, and a deployed configuration comprising at least two turns;
• a second catheter comprising a second lumen;
• a replacement valve, wherein the replacement valve comprises an expandable frame comprising a plurality of wires woven together and a valve body, wherein the valve body comprises multiple pieces of tissue that together form leaflets that can open to allow blood flow therethrough and close to prevent blood flow therethrough;
• wherein the replacement valve can transition from a collapsed configuration, in which the replacement valve can be disposed within the second lumen for transvascular delivery through the opening in the femoral vein to the cardiac valve, to an expanded configuration;
• and
• wherein the anchor can be transvascularly delivered through the first lumen of the first catheter to the cardiac valve, and the replacement valve is configured such that the replacement valve can be transvascularly delivered through the second lumen of the second catheter to the cardiac valve in the collapsed configuration and expanded to the expanded configuration inside the anchor and thereby secure the replacement valve and the anchor at the cardiac valve.

A system comprising:

• a catheter comprising a lumen, a proximal end, and a distal end;
• a handle connected to the catheter at the proximal end of the catheter;
• an anchor, wherein the anchor is transitionable between a straightened configuration, which can be disposed within the lumen for transvascular delivery through an opening in a blood vessel to a cardiac valve of a heart, and a deployed configuration comprising at least two turns;
• a replacement valve, wherein the replacement valve comprises an expandable frame and a valve body, wherein the valve body comprises multiple pieces of animal tissue sewn or bonded together to form replacement leaflets that can open to allow blood flow therethrough and close to prevent blood flow therethrough;
• wherein the replacement valve can transition from a collapsed configuration, for transvascular delivery through the opening in the blood vessel to the cardiac valve, to an expanded configuration;
• wherein the anchor can be transvascularly delivered through the lumen of the catheter to the cardiac valve such that at least one of the at least two turns encircles leaflets of the cardiac valve, and the replacement valve is configured such that the replacement valve can be transvascularly delivered to the cardiac valve in the collapsed configuration and expanded to the expanded configuration inside the anchor and thereby secure the replacement valve and the anchor at the cardiac valve;
• and
• wherein the replacement valve in the expanded configuration is configured to have a diameter smaller than a major axis of the cardiac valve, such that native commissural regions of the cardiac valve extend radially beyond the replacement valve.

A system comprising:

• a catheter comprising a lumen, a proximal end, and a distal end;
• a handle connected to the catheter at the proximal end of the catheter;
• an anchor, wherein the anchor is transitionable between a straightened configuration, which can be disposed within the lumen for transvascular delivery through an opening in a blood vessel to a cardiac valve of a heart, and a deployed configuration comprising at least two turns;
• a replacement valve, wherein the replacement valve comprises an expandable frame and a valve body, wherein the valve body comprises multiple pieces of animal tissue sewn or bonded together to form replacement leaflets that can open to allow blood flow therethrough and close to prevent blood flow therethrough;
• wherein the replacement valve can transition from a collapsed configuration, for transvascular delivery through the opening in the blood vessel to the cardiac valve, to an expanded configuration;
• wherein the anchor can be transvascularly delivered through the lumen of the catheter to the cardiac valve such that at least one of the at least two turns encircles leaflets of the cardiac valve, and the replacement valve is configured such that the replacement valve can be transvascularly delivered to the cardiac valve in the collapsed configuration and expanded to the expanded configuration inside the anchor and thereby secure the replacement valve and the anchor at the cardiac valve;
• and
• wherein the at least two turns of the anchor in the deployed configuration are configured to have a diameter smaller than a major axis of the cardiac valve, such that native commissural regions of the cardiac valve extend radially beyond the at least two turns of the anchor.

A system comprising:

• a catheter comprising a lumen, a proximal end, and a distal end;
• a handle connected to the catheter at the proximal end of the catheter;
• an anchor, wherein the anchor is transitionable between a straightened configuration, which can be disposed within the lumen for transvascular delivery through an opening in a blood vessel to a mitral valve of a heart, and a deployed configuration comprising at least two turns;
• a replacement valve, wherein the replacement valve comprises an expandable frame and a valve body, wherein the valve body comprises multiple pieces of animal tissue sewn or bonded together to form replacement leaflets that can open to allow blood flow therethrough and close to prevent blood flow therethrough;
• wherein the replacement valve can transition from a collapsed configuration, for transvascular delivery through the opening in the blood vessel to the mitral valve, to an expanded configuration;
• wherein the anchor can be transvascularly delivered through the lumen of the catheter to the mitral valve such that at least one of the at least two turns encircles leaflets of the mitral valve, and the replacement valve is configured such that the replacement valve can be transvascularly delivered to the mitral valve in the collapsed configuration and expanded to the expanded configuration inside the anchor and thereby secure the replacement valve and the anchor at the mitral valve;
• and
• wherein the anchor and the replacement valve are configured to be implanted at the mitral valve without contacting an entire circumference of an annulus of the mitral valve.