DNA molecules encoding antibodies to tau and methods of making thereof
AssigneeEli Lilly and Company
InventorsMansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
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Abstract
Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
Claims13
A DNA molecule comprising a polynucleotide sequence encoding a light chain (LC) of an antibody that binds human tau, the LC comprising a light chain variable region (LCVR) having the amino acid sequence of SEQ ID NO:
- 9 and comprising a polynucleotide sequence encoding a heavy chain (HC) of the antibody, the HC comprising a heavy chain variable region (HCVR) having the amino acid sequence of SEQ ID NO:
- 10.
A mammalian cell comprising a DNA molecule comprising a polynucleotide sequence encoding a LC of an antibody that binds human tau, the LC comprising a LCVR having the amino acid sequence of SEQ ID NO:
- 9 and a DNA molecule comprising a polynucleotide sequence encoding a HC of an antibody that binds human tau, the HC comprising a HCVR having the amino acid sequence of SEQ ID NO:
- 10, wherein the cell is capable of expressing the antibody.
Dependencies are inferred from the claim text.