Non-lactone carbocyclic modulators of bacterial quorum sensing

Abstract

Non-lactone carbocyclic modulators of bacterial quorum sensing. Pharmaceutical composition containing such modulators. Methods employing such modulators for modulation of quorum sensing. Compounds are exemplified by those of formula: A-[Z]n-L1-[Y]—NH-L2-HG, where A is an optionally substituted aryl or heteroaryl group having one or two 5- or 6-member rings with up to 1-3 heteroatoms in a ring, or a substituted or unsubstituted C1-C12 acyclic aliphatic group and HG is an optionally substituted cyclopentyl group. Compounds include those where n is 1 or 0, Z is —CO—, —O—CO—, —CO—O—, —NH—CO—, —CO—NH—, —NH—CO—NH—, —O—, —S—, or —NH2, Y is —NH—CO—, —CO—CH2—C(Y1)-, or —SO2—, where Y1 is —OH, —SH, —NH2 or —F; and L1 and L2 independently are —[CH2]p1- and —[CH2]p2-, where p1 and p2, independently, are 0 or integers ranging from 1-3.

Dependencies are inferred from the claim text.