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US 10,806,733 B2Granted
Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
AssigneeGlobal Blood Therapeutics, Inc.
InventorsBrian Metcalf, Chihyuan Chuang
Life of this patent
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Abstract
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
Claims7
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Q is a pyridin-2-yl, pyridin-3-yl, or pyridin-4-yl, each of which is substituted with one Ra;
- R2, R3, and R4 are each hydrogen;
- Y is CH2;
- X is O or CH2;
- R5 is halo or OH;
- R6 and R7 together form oxo;
- Ra is heteroaryl substituted with one to three Rc;
- and
- each Rc is independently selected from the group consisting of C1-8alkyl and haloC1-8 alkyl.
7 more elements
Dependencies are inferred from the claim text.