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US 10,806,708 B2Granted
Affinity medicant conjugate
AssigneeAF Chemicals, LLC
InventorMichael J Kelner
Life of this patent
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Abstract
In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a toxin including an acylfulvene or a drug moiety. The affinity moiety can be an antibody, a binding protein, a steroid, a lipid, a growth factor, a protein, a peptide or non peptidic. The affinity moiety can be covalently bound to the medicant via a linker. Novel linkers that can be directed to cysteine, arginine or lysine residues based on solution pH allow greater flexibility in preserving and/or generating specific epitopes in the AMC.
Claims1
A compound of the formula:
- or a pharmaceutically acceptable salt thereof, where X represents an oxygen atom, where R1, R3 and R5 are —CH3, where R4 and R6 are —H, where R2 is —CH2—R7, where R7 is —OAc where Ac is —C(═O)CH3.
Dependencies are inferred from the claim text.