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US 10,806,702 B2Granted
Bis-polymer lipid-peptide conjugates and nanoparticles thereof
AssigneeThe Regents of the University of California
InventorsTing Xu, He Dong, Jessica Shu, Nikhil Dube
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Abstract
The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.
Claims12
A conjugate comprising:
- a first peptide having from 10 to 100 amino acids, wherein the peptide adopts a helical structure;
- a first polymer covalently linked to an amino acid residue of the peptide, other than the N-terminal and C-terminal amino acid residues;
- at least one second polymer covalently linked to the C-terminal amino acid residue of the peptide, wherein the second polymer is other than an amino acid polymer;
- and
- a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a third polymer or a lipid moiety.
2 more elements
Dependencies are inferred from the claim text.