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US 10,806,701 B2Granted
Aerosol formulation for COPD
AssigneeChiesi Farmaceutici S.p.A.
InventorsSauro Bonelli, Francesca Usberti, Enrico Zambelli
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Abstract
Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.
Claims13
A pharmaceutical composition for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide dissolved in HFA-134a and ethanol, wherein:
- the composition comprises an amount of hydrochloric acid equivalent to 0.005 to 1.0 μg/μl of 1M hydrochloric acid;
- the composition comprises glycopyrronium bromide in an amount of 0.015 to 0.04% w/w of the composition;
- the composition comprises ethanol in an amount of 10 to 15% w/w of the composition;
- and
- the composition comprises HFA-134a in an amount of 85 to 90% w/w of the composition.
2 more elements
Dependencies are inferred from the claim text.