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US 10,802,026 B2Granted
Biomarkers for the early detection of breast cancer
AssigneesArizona Board of Regents, a body corporate acting for and on behalf of Arizona State University, Dana-Farber Cancer Institute, Inc., President and Fellows of Harvard College
InventorsJoshua Labaer, Karen Sue Anderson, Garrick Wallstrom, Sahar Sibani, Niroshan Ramachandran
Life of this patent
Estimating the term…
Abstract
The present invention provides reagents and methods for breast cancer detection.
Claims5
A method for treating breast cancer, comprising;
- administering a therapeutic agent to the subject to treat the breast cancer, wherein the subject is identified as having breast cancer by
- (i) contacting a bodily fluid sample obtained from the subject with a PDCD6IP (SEQ ID NO:
- 21) polypeptide and a HOXD1 (SEQ ID NO:
- 7) polypeptide and one or more additional isolated polypeptides selected from the group consisting of ATP6AP1 (SEQ ID NO:
- 13), DBT (SEQ ID NO:
- 25), CSNK1E (SEQ ID NO:
- 9), FRS3 (SEQ ID NO:
- 3), RAC3 (SEQ ID NO:
- 15), SF3A1 (SEQ ID NO:
- 1), CTBP1 (SEQ ID NO:
- 29), C15orf48 (SEQ ID NO:
- 35), MYOZ2 (SEQ ID NO:
- 33), EIF3E (SEQ ID NO:
- 39), BAT4 (SEQ ID NO:
- 5), ATF3 (SEQ ID NO:
- 19), BMX (SEQ ID NO:
- 45), RAB5A (SEQ ID NO:
- 23), UBAP1 (SEQ ID NO:
- 47), SOX2 (SEQ ID NO:
- 31), GPR157 (SEQ ID NO:
- 43), BDNF (SEQ ID NO:
- 17), ZMYM6 (SEQ ID NO:
- 41), SLC33A1 (SEQ ID NO:
- 11), TRIM32 (SEQ ID NO:
- 37), ALG10 (SEQ ID NO:
- 27), TFCP2 (SEQ ID NO:
- 49), SERPINH1 (SEQ ID NO:
- 51), SELL (SEQ ID NO:
- 55), ZNF510 (SEQ ID NO:
- 53), or antigenic fragments thereof;
- wherein the contacting occurs under conditions whereby antibodies, if present in the bodily fluid, selectively bind to the polypeptides and
- (ii) detecting presence of antibodies to the polypeptides in the bodily fluid sample.
29 more elements
Dependencies are inferred from the claim text.