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US 10,802,021 B2Granted
Synthetic hybrid receptor and genetic circuit in bacteria to detect enteric pathogenic microorganisms
AssigneesMassachusetts Institute of Technology, Trustees of Boston University
InventorsNing Mao, Douglas Ewen Cameron, James Collins
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Abstract
Provided herein are microorganisms engineered with hybrid receptors and genetic circuits. Also provided are hybrid receptors having a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system. Methods for using engineered microorganisms to sense and destroy pathogens (e.g., Vibrio cholerae) are also provided.
Claims20
An engineered microorganism comprising
- a hybrid receptor comprising at least the binding portion of a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system;
- and
- a genetic circuit responsive to the heterologous histidine kinase.
A hybrid receptor comprising
- at least the binding portion of a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system.
Dependencies are inferred from the claim text.