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US 10,800,754 B2Granted
Heterocyclic amide compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsTakaharu Hirayama, Yasuhiro Hirata, Yusuke Tominari, Naoki Iwamura, Yusuke Sasaki, Moriteru Asano, Terufumi Takagi, Masanori Okaniwa, Masato Yoshida, Shinichi Imamura
Life of this patent
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Abstract
Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
Claims2
A compound represented by the following formula (I):
- wherein a group represented by
- is a C6-14 aryl group, thienyl or benzothienyl, each of which is optionally substituted by 1 to 5 substituents selected from the group consisting of:
- (1) a halogen atom,
- (2) a cyano group,
- (3) a C1-6 alkyl group optionally substituted by 1 to 3 halogen atoms,
- (4) a C6-14 aryl group,
- (5) a C1-6 alkoxy group, and
- (6) thienyl, pyrazolyl, imidazolyl, thiazolyl, isothiazolyl, triazolyl, pyridyl or pyridazinyl, each of which is optionally substituted by 1 to 3 substituents selected from the group consisting of:
- (i) a cyano group,
- (ii) a halogen atom,
- (iii) a C1-12 alkyl group optionally substituted by 1 to 6 substituents selected from the group consisting of (a) a halogen atom, (b) a cyano group, (c) a hydroxy group, (d) a C3-10 cycloalkyl group optionally substituted by 1 to 3 halogen atoms, (e) a C1-6 alkoxy group optionally substituted by a C1-6 alkoxy group, (f) a C6-14 aryl group, (g) a C1-6 alkoxy-carbonyl group, (h) a carbamoyl group, (i) a C1-6 alkyl-sulfonyl group, (j) oxetanyl, tetrahydrofuranyl, tetrahydropyranyl or 1,4-dioxanyl, each of which is optionally substituted by 1 to 3 C1-6 alkyl groups, and (k) pyrazolyl, imidazolyl or pyridyl,
- (iv) a C3-10 cycloalkyl group,
- (v) tetrahydrofuranly,
- (vi) a C1-6 alkoxy-carbonyl, and
- (vii) an oxo group;
- R1 is
- (1) a hydrogen atom,
- (2) a halogen atom,
- (3) an alkyl group optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, a cyano group, a hydroxy group, and a C1-6 alkoxy group,
- (4) an alkynyl group optionally substituted by a hydroxy group, or
- (5) a hydroxy group optionally substituted by a C1-6 alkyl group;
- X1 is CR2a (R2a is a hydrogen atom or a halogen atom) or a nitrogen atom;
- X2 is CR3a (R3a is a hydrogen atom or a halogen atom) or a nitrogen atom;
- X3 is CR4bR5b (R4b is a cyano group and R5b is a C3-10 cycloalkyl group);
- X4 is CR7bR8b (R7b and R8b are each independently (1) a hydrogen atom or (2) a C1-6 alkyl group optionally substituted by 1 to 3 substituents selected from the group consisting of a cyano group, a hydroxy group, and a C1-6 alkoxy group);
- and
- X5 is CR9bR10b (R9b and R10b are each independently a hydrogen atom or a C1-6 alkyl group),
- or a salt thereof.
25 more elements
Dependencies are inferred from the claim text.