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US 10,800,733 B2Granted
Acetophenone compound, preparation method therefor, and application thereof in blood lipid regulation
AssigneeShanghai Bioenergy Medicine Science & Technology Co., Ltd.
InventorsYuqiong Dong, Quanhai Liu, Yu Shen, Wentao Cai
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Abstract
Disclosed are a compound represented by Formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, the Formula I, and an application thereof in preparing drugs for regulating blood lipids.
Claims8
A compound of Formula I or a pharmaceutically acceptable salt thereof,
- wherein,
- X is oxygen;
- R1 is selected from hydroxyl;
- R2 is selected from the substituted pyridyl, wherein the substituent for pyridyl is halogen;
- hydroxyl;
- C1-C6 alkyl;
- C1-C6 alkoxy;
- C1-C6 haloalkoxy;
- C1-C6 haloalkyl;
- C3-C6 cycloalkyl.
7 more elements
A compound or a pharmaceutically acceptable salt thereof, comprising the following structural formula:
A method of preparing the compound of Formula I or a pharmaceutically acceptable salt thereof
- wherein,
- X is oxygen;
- R1 is selected from hydroxyl;
- R2 is selected from the substituted pyridyl, wherein the substituent for pyridyl is halogen;
- hydroxyl;
- C1-C6 alkyl;
- C1-C6 alkoxy;
- C1-C6 haloalkoxy;
- C1-C6 haloalkyl;
- C3-C6 cycloalkyl,
- the method comprising:
- Method I, comprising a step of directly condensing an acid
- and a compound
- in the presence of a condensing agent and a solvent;
- or
- Method II, comprising a step of condensing an acyl chloride and a compound
- in a solvent, wherein the acyl chloride is obtained by a reaction of an acid
- with a chlorinating agent.
15 more elements
Dependencies are inferred from the claim text.