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US 10,799,575 B2Granted
Flavivirus and alphavirus virus-like particles (VLPS)
AssigneeTechnoVax, Inc.
InventorsJose M. Galarza, Helene Boigard, George Martin
Life of this patent
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Abstract
Described herein are flavivirus virus-like particles (VLPs) that display on their surfaces antigenic flavivirus proteins. Also described are methods of making and using these VLPs.
Claims21
A virus-like particle (VLP) comprising
- at least one flavivirus structural protein;
- and
- at least one non-structural flavivirus protein,
- wherein the VLP:
- (i) is a single bivalent VLP that displays on its surface an E antigen of two flavivirus serotypes or clades;
- or (ii) a multivalent VLP that displays on its surface an E antigen of multiple flavivirus serotypes or clades, and wherein the VLP comprises E antigens from at least two different flaviviruses, and wherein the at least one flavivirus structural protein is from a flavivirus of the Flavivirus genus, and
- wherein the at least one non/structual flavivirus protein comprises a truncated NS3 protein co-expressed with a truncated NS2B protein having an amino acid sequence of SEQ ID NO:
- 9.
5 more elements
Dependencies are inferred from the claim text.