Retro- and lenti-HBV hybrid vectors and constructs
AssigneeVirongy L.L.C.
InventorYuntao Wu
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Abstract
The present disclosure relates to the design of a retro- or lenti-viral HBV (hepatitis B virus) hybrid vector for delivery of HBV genomes into cells such as liver cells. Provided herein are design, methodology, compositions, and the like for such vectors for delivering HBV genes or genomes into cells for anti-HBV drug screening, HBV research, or test of anti-HBV therapeutics.
Claims9
A retro- or lenti-viral HBV (hepatitis B virus) hybrid vector, comprising a HBV genome, wherein said hybrid vector is transcribed 3′-5′, and comprises a HIV 5′ LTR (long terminal repeat), ψ HIV genome packaging signal, HIV RRE (Rev-dependent element), and at least one of HIV 3′ LTR (long terminal repeat) or HIV 3′ SIN LTR (self-inactivating LTR with ΔU3 deletion).
A retro- or lenti-viral HBV (hepatitis B virus) hybrid vector, comprising a HBV genome, wherein said hybrid vector is transcribed 3′-5′, and comprises a HIV 5′ LTR (long terminal repeat), ψ HIV genome packaging signal, HIV RRE (Rev-dependent element), and at least one of HIV 3′ LTR (long terminal repeat) or HIV 3′ SIN LTR (self-inactivating LTR with ΔU3 deletion), wherein said vector comprises a HBV genome with one or more mutations useful for detecting an anti-HBV drug target or therapeutic.
Dependencies are inferred from the claim text.