Chimeric adeno-associated virus/ bocavirus parvovirus vector
AssigneesUniversity of Iowa Research Foundation, University of Kansas
InventorsZiying Yan, John F. Engelhardt, Jianming Qiu
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Abstract
The invention provides an isolated chimeric virus comprising bocavirus capsid protein and a recombinant adeno-associated viral (AAV) genome, an isolated rBoV comprising human bocavirus capsid protein and a recombinant BoV genome, and uses therefor. For example, the chimeric virus may be employed to deliver transgenes, such as those encoding therapeutic or prophylactic gene products, to mammalian cells.
Claims15
A method to express a heterologous gene product in mammalian cells comprising providing isolated chimeric virus comprising human bocavirus (BoV) capsid protein and a recombinant adeno-associated viral (AAV) genome comprising an expression cassette encoding the heterologous gene product;
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- infecting mammalian cells having the tropism of human bovavirus with the chimeric virus an amount effective to express the heterologous gene product.
Dependencies are inferred from the claim text.