Back to results
US 10,793,832 B2Granted
Pancreatic endocrine cells, method for producing same, and transdifferentiation agent
AssigneeJuntendo Educational Foundation
InventorsMasahito Matsumoto, Yasushi Okazaki, Izumi Sugahara
Life of this patent
Estimating the term…
Abstract
A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.
Claims8
A method for transdifferentiating somatic cells into pancreatic endocrine cells, the method comprising
- introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into the somatic cells,
- wherein the one or more genes of a GLIS family or one or more gene products thereof is selected from the group consisting of GLIS1 and GLIS3 and wherein the somatic cells transdifferentiate into the pancreatic endocrine cells without undergoing an iPS cell stage.
Dependencies are inferred from the claim text.