Transgenic mammals and methods of use thereof
AssigneeTrianni, Inc.
InventorMatthias Wabl
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Abstract
The present invention relates to transgenic mammals that express bovine-based immunoglobulins, including transgenic rodents that express bovine-based immunoglobulins for the development of bovine therapeutic antibodies.
Claims13
A transgenic mouse with a genome in which a mouse endogenous immunoglobulin variable gene locus has been deleted and replaced with an engineered partly bovine immunoglobulin locus comprising bovine immunoglobulin variable gene VH, DH and JH and/or bovine VL and JL coding sequences and mouse immunoglobulin variable gene locus non-coding regulatory and/or scaffold sequences, wherein the engineered partly bovine immunoglobulin locus of the transgenic mouse is functional and expresses immunoglobulin chains comprised of bovine variable domains and mouse constant domains.
Dependencies are inferred from the claim text.