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US 10,793,614 B2Granted
Antagonists of fish reproduction
AssigneeYissum Research Development Company of the Hebrew University ofJerusaIem Ltd.
InventorsBerta Levavi-Sivan, Chaim Gilon
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Abstract
Peptide-based neurokinin antagonists of fish reproduction are disclosed. Compositions comprising antagonists of fish neurokinin and methods of inhibiting or delaying puberty, fish maturation or reproduction processes using these compounds are also provided.
Claims20
A peptidomimetic of 6-10 amino acid residues comprising the sequence X1-NMeVal-βAla-Leu-Met-Z (SEQ ID NO:
- 7), wherein X1 consists of 2 or 3 amino acid residues comprising an aromatic residue, a negatively charged acidic residue, and optionally an N-terminal capping moiety or modification;
- and Z represents the C-terminus of the peptide which may be amidated, acylated, reduced or esterified.
Dependencies are inferred from the claim text.