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US 10,793,533 B2Granted
Dimeric contrast agents
AssigneeBracco Imaging S.P.A.
InventorsValeria Boi, Roberta Napolitano, Luciano Lattuada, Giovanni Battista Giovenzana
Life of this patent
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Abstract
The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Claims22
A compound of formula (I)
- where:
- R is —CH(R1)—COOH, where:
- R1 is H or a C1-C3 alkyl chain that is optionally substituted by a C1-C3 alkoxy or C1-C3 hydroxyalkoxy group;
- n is 1 or 2;
- d is 0 or 1;
- R2 is a C1-C5 alkyl substituted by from 1 to 3 groups X where:
- X is a group of formula —O—[CH(CH2O—)2]s(R3)s+1 or —O—(CH2CH2O—)r—R3,
- in which:
- R3 is H or a C1-C3 alkyl group, bound to the respective oxygen atom(s) of terminal units —CH(CH2O—) or —(CH2CH2O—) of X;
- r is 1, 2, 3, 4, 5, 6, 7 or 8;
- and
- s is 1, 2 or 3;
- with the proviso that when the C1-C5 alkyl in R2 is substituted by a single group X, r and s are not 1,
- as well as individual diastereoisomers and their racemic mixtures, and solved enantiomers of the same, and the physiologically acceptable salts thereof.
11 more elements
A compound of formula (1)
- where:
- R is CH(R1)—COOC(CH3)3, where:
- R1 is H or a C1-C3 alkyl chain that is optionally substituted by a C1-C03 alkoxy or a C1-C3 hydroxyalkoxy group;
- n is 1 or 2;
- d is 0 or 1;
- R2 is a C1-C5 alkyl substituted by from 1 to 3 groups X where:
- X is a group of formula —O—[CH(CH2O—)2]s(R3)s+1 or —O—(CH2CH2O—)rR3,
- in which:
- R3 is H or a C1-C3 alkyl group, bound to the respective oxygen atom(s) of terminal units —(CH(CH2O—) or —(CH2CH2O—) of X;
- r is 1, 2, 3, 4, 5, 6, 7 or 8;
- and
- s is 1, 2, or 3;
- with the proviso that when the C1-C5 alkyl in R2 is substituted by a single group X,
- r and s are not 1.
11 more elements
Dependencies are inferred from the claim text.