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US 10,792,358 B2Granted
ISG15 and its use as an adjuvant
AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid Weiner, Daniel Villarreal
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a vaccine comprising an antigen and ISG15. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. Further disclosed herein is a method for treating a subject in need thereof. The methods may comprise administering the vaccine to the subject.
Claims16
A vaccine comprising:
- a) an antigen, a nucleic acid molecule encoding an antigen, or a combination thereof;
- and
- b) a nucleic acid molecule comprising a nucleotide sequence encoding ISG15, wherein the nucleotide sequence encoding ISG15 comprises one or more nucleotide sequences selected from the group consisting of a nucleotide sequence having at least about 95% identity to the nucleotide sequence as set forth in SEQ ID NO:5 and the nucleotide sequence as set forth in SEQ ID NO:5.
A nucleic acid molecule comprising one or more nucleotide sequences selected from the group consisting of:
- a nucleotide sequence having at least about 95% identity to the nucleotide sequence as set forth in SEQ ID NO:5, and the nucleotide sequence as set forth in SEQ ID NO:5.
Dependencies are inferred from the claim text.