Optimized HIV envelope gene and expression thereof
AssigneeInternational AIDS Vaccine Initiative
InventorsChristopher L. Parks, Maoli Yuan, Xinsheng Zhang, Aaron Wilson, Angela Grazia Lombardo, Eddy Sayeed, Josephine Helena Cox, Takashi Hironaka, Makoto Inoue, Hiroto Hara
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Abstract
The present invention relates to a vector(s) containing and expressing an optimized HIV EnvF gene, methods for making the same and cell substrates qualified for vaccine production which may comprise vector(s) containing optimized HIV genes.
Claims9
A viral vector containing and expressing a nucleic acid encoding a Clade A Env-F hybrid based on BG505, wherein the Env signal sequence (SS), transmembrane region (TMR), and the cytoplasmic tail (CT) of HIV-Env-F are replaced with an analogous sequence from the Sendai virus F gene.
Dependencies are inferred from the claim text.