Pre-operative simulation of trans-catheter valve implantation

A method for implanting a heart valve implant in a patient, the method comprising:

• obtaining 2D or 3D medical image data of an aorta and aortic valve of the patient;
• estimating a patient-specific anatomical model of the aorta and aortic valve of the patient based on the 2D or 3D medical image data;
• generating an aortic mesh using segmentation techniques, said aortic mesh comprising a finite number of elements based on the 2D or 3D medical image data, said aortic mesh representing the aorta and the aortic valve, said valve comprising 2 or 3 valve leaflets, wherein each of the finite number of elements of said mesh is featured by a set of nodes and adjacent elements of said finite number of elements comprise mutually-shared nodes, wherein at least some of the finite number of elements differ in tissue dependent parameters from an adjacent element of said finite number of elements;
• for each of said valve leaflets, selecting a number of leaflet attachment points on said aortic mesh;
• for each of said valve leaflets, estimating a number of leaflet points;
• for each of said valve leaflets, mapping said leaflet points and said leaflet attachment points to a transformed leaflet mesh, wherein the elements of said transformed leaflet mesh are featured by normal or aberrant tissue parameters;
• deploying an implant model representing implantation of the heart valve implant into said aortic mesh,
• wherein said implant model comprises a mesh of finite elements wherein at least some of the elements of said mesh are featured by a set of nodes wherein
• adjacent elements of said mesh of finite elements comprise mutually shared nodes, wherein said mesh of finite elements is featured by material dependent parameters, and wherein each element of said mesh can differ in material dependent parameters from an adjacent element of said mesh,
• wherein said patient-specific anatomical model comprises an anatomical model of a blood channel that comprises said transformed leaflet meshes;
• and
• wherein said deploying an implant model comprises employing a three-dimensional finite element analysis into the patient-based anatomical model;
• wherein the deployed implant model comprises a virtual percutaneous implant deployment step which comprises taking into account the impact of the surrounding anatomical structures by adding springs on an aortic surface of the aortic mesh, which springs represent the stiffness or resistance of the surrounding structures and structures of the aorta;
• determining a deformation of the implant model and the aortic mesh;
• creating a blood mesh comprising a finite volume mesh, wherein the blood mesh represents the volume within said aortic mesh comprising the deployed implant model;
• calculating a blood flow for said blood mesh using computational fluid dynamics analysis;
• determining a likelihood of blood backflow or regurgitation based on the calculated blood flow based on the deformation of the implant model and the aortic mesh;
• selecting a heart valve implant having a size adapted to an anatomy of the patient based on a determination of a lower likelihood of blood backflow or regurgitation by the heart valve implant based on a clinically used scale to grade blood backflow or regurgitation;
• and
• implanting the heart valve implant in the patient.