US 10,788,493 B2 · Composition for diagnosing infectious diseases or infectious complications by using tryptophanyl-tRNA synthetase and method for detecting diagnostic marker

Abstract

The present invention relates to a composition for diagnosing infectious diseases by using a tryptophanyl-tRNA synthase (WRS) and a method for detecting a diagnostic marker and, more specifically, to: a composition for diagnosing infectious diseases, containing a preparation measuring the WRS protein or mRNA expression level; a diagnostic kit; a method for detecting the WRS for providing information required for the diagnosis of infectious diseases, and a method for determining the infectious disease mortality risk by using the WRS. According to the present invention, the WRS is increased only in infection-induced infectious diseases, differentiating non-infectious diseases therefrom, and is rapidly increased in the early stage of infection. In addition, the level of the WRS is closely correlated with the severity and prognosis of diseases or complications induced by infection. Therefore, the WRS can be used as a marker for more rapid and accurate diagnosis, in comparison to a conventional marker for infectious diseases or complications thereof.

Claims6

Dependent claims

A method for diagnosing and treating sepsis or septic shock, the method comprising:

measuring a level of tryptophanyl-tRNA synthetase protein in a cell-free sample collected from a human subject suspected of suffering from sepsis or septic shock, wherein the tryptophanyl-tRNA synthetase protein comprises the amino acid sequence of SEQ ID NO:
1;
identifying the subject as having an increased level of the tryptophanyl-tRNA synthetase protein compared to the level of the tryptophanyl-tRNA synthetase protein in a cell-free sample from a healthy subject;
and
administering an antibiotic agent, an antiviral agent or an antifungal agent to the subject.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/908,568Filed 28 Feb 2018 · continuation in part

Priority

KR 10-2015-01237431 Sep 2015

Published

US 2018/0275127 A127 Sep 2018

Granted

29 Sep 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

G01N 33/573
Immunoassay; Biospecific binding assay; Materials therefor: for enzymes or isoenzymes
C07K 16/40
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against enzymes
C12Q 1/68
Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such…
C12Q 1/6813
Involving nucleic acids: hybridisation assays

Composition for diagnosing infectious diseases or infectious complications by using tryptophanyl-tRNA synthetase and method for detecting diagnostic marker

Life of this patent

Composition for diagnosing infectious diseases or infectious complications by using tryptophanyl-tRNA synthetase and method for detecting diagnostic marker

Life of this patent

Abstract

Claims6