Compounds and methods for activating the apoptotic arm of the unfolded protein response
AssigneesUniversity of Kansas, The Regents of the University of Michigan, Sanford-Burnham Medical Research Institute, Wayne State University
InventorsJennifer E. Golden, Jeffrey Aube, Daniel P. Flaherty, Andrew M. Fribley, Randal J. Kaufman, Thomas D. Y. Chung, Anthony B. Pinkerton, Michael Pablo Hedrick
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Abstract
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
Claims1
A method of treating an oral squamous cell carcinoma, ovarian cancer or leukemia, in a subject comprising administering to a subject in need of treatment, a pharmaceutical composition comprising the compound:
- thereby treating the subject's oral squamous cell carcinoma, ovarian cancer or leukemia.
Dependencies are inferred from the claim text.