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US 10,786,606 B2Granted
Functional coating
AssigneeAnteo Technologies Pty Ltd
InventorsNobuyoshi Joe Maeji, Chang-Yi Huang
Life of this patent
Estimating the term…
Abstract
The present invention relates to the coating of a range of functional heparins onto the surface of a substrate for which hemocompatibility is a key functional characteristic, such that the functionality of the functional heparin is maintained. The approach employs a metal coordination complex to bind to the substrate with the functional heparin binding to the metal coordination complex to thereby impart hemocompatibility.
Claims18
A substrate having a hemocompatible coating comprising:
- (a) an oligomeric metal ion coordination complex comprising bridging ligands having a dative bond forming atom selected from nitrogen, oxygen, and sulfur, each datively bonded to at least two central metal ions, the oligomeric metal ion coordination complex bonded directly to a surface of the substrate through one or more coordinate bonds formed between the metal ions of the oligomeric metal ion coordination complex and the substrate surface;
- and
- (b) a functional heparin layer bonded directly to metal ions of the oligomeric metal ion coordination complex through one or more coordinate bonds;
- wherein, the oligomeric metal ion coordination complex is a separate layer from and is of a different character to the surface of the substrate, but is bonded to the surface of the substrate.
1 more element
A method of forming a hemocompatible coating on a substrate including the steps of:
- (a) forming a metal coordination complex layer on a surface of the substrate, wherein the metal coordination complex layer comprises an oligomeric metal ion coordination complex comprising bridging ligands having a dative bond forming atom selected from nitrogen, oxygen, and sulfur, each datively bonded to at least two central metal ions, the oligomeric metal ion coordination complex bonded directly bonded to a surface of the substrate through one or more coordinate bonds formed between the metal ions of the oligomeric metal ion coordination complex and the substrate surface;
- (b) coating the metal coordination complex with a functional heparin such that the functional heparin bonds directly to metal ions of the oligomeric metal ion coordination complex through one or more coordinate bonds,
- to thereby form the hemocompatible coating on the substrate.
Dependencies are inferred from the claim text.