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AssigneeNovartis AG
InventorsAlexandra Marshall Bruce, Aaron Kanter, Changgang Lou, Aimee Richardson Usera, Jun Yuan, Frederic Zecri
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The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
A method of treating or preventing a disease or disorder selected from metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, nonalcoholic steatohepatitis, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications, chronic kidney disease, neuropathy, and gastroparesis, in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a conjugate comprising a biomolecule linked to a fatty acid via a linker,
A method of treating or preventing a disease or disorder selected from type 2 diabetes mellitus, obesity, cardiovascular disease, and heart failure, in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a conjugate of Formula G or of Formula H or a mixture of conjugates comprising the conjugate having Formula G and the conjugate having Formula H:
A method of treating or preventing a disease or disorder selected from type 2 diabetes mellitus, obesity, cardiovascular disease, and heart failure, in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a conjugate of Formula G or of Formula H or a mixture of conjugates comprising the conjugate having Formula G and the conjugate having Formula H:
Dependencies are inferred from the claim text.