Streptococcus agalactiae antigens associated with strains virulent in fish
AssigneeMoredun Research Institute
InventorsMichael Fontaine, Ruth Nicolet Zadoks, Christian Marie Joseph Delannoy
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Abstract
The present disclosure is based upon the identification of a number of Streptococcus agalactiae genes which are required for virulence in fish species. Specifically, the disclosure relates to genomic content present in fish-associated S. agalactiae strains that is absent from strains which are non-virulent to fish. Further disclosed is the use of a number of S. agalactiae proteins and antigens in methods, immunogenic compositions and vaccines for raising immune responses and treating or preventing diseases, conditions and/or infections with a Streptococcal aetiology.
Claims4
A method of raising an immune response or treating or preventing a disease, condition or infection with a streptococcal aetiology, in a fish, said method comprising administering an animal in need thereof an immunogenic amount of an immunogenic composition or vaccine comprising an antigen having at least 90% sequence identity to the S. agalactiae antigen, sugar ABC transporter sugar-binding protein.
Dependencies are inferred from the claim text.