Atmospheric-pressure ionization and fragmentation of molecules for structural elucidation
AssigneesIndiana University Research and Technology Corporation, Kent State University
InventorsJacob T. Shelley, Kelsey L. Williams, Gary M. Hieftje, Andrew J. Schwartz
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Abstract
A solution-cathode glow discharge (SCGD) spectrometry apparatus may comprise an SCGD source and a mass or ion mobility spectrometer. A method for ionizing a molecular analyte may comprise contacting the molecular analyte with a plasma discharge to form ions and separating the ions in a mass spectrometer or ion mobility spectrometer. The contacting step may occur under atmospheric pressure and/or ambient conditions. The molecular analyte may be fragmented by the plasma discharge.
Claims18
A method for ionizing a molecular analyte, the method comprising:
- contacting the molecular analyte with a plasma discharge under ambient conditions to form ions by flowing an electrically conductive liquid through a capillary onto a first conductive rod that surrounds the capillary and applying an electric potential to a second conductive rod such that the plasma discharge forms between the second conductive rod and the electrically conductive liquid to produce the ions, and
- separating the ions in a mass spectrometer.
Dependencies are inferred from the claim text.