Dibasic organic acid producing strain and preparation and application of same

An engineered strain for synthesizing a dibasic organic acid, wherein the engineered strain is capable of producing the dibasic organic acid at a fermentation temperature of 40-60° C. by using glycan and/or biomass as a fermentation substrate,

• wherein the original strain of the engineered strain is selected from the group consisting of Myceliophthora thermophila and Myceliophthora heterothallica;
• the engineered strain is introduced with a positive regulator gene for synthesizing the dibasic organic acid, up-regulates expression of the positive regulator gene for synthesizing the dibasic organic acid, and/or down-regulates expression of a negative regulator gene for synthesizing the dibasic organic acid,
• wherein an expression product of the positive regulator gene comprises one or more polypeptides selected from the group consisting of aspartate aminotransferase, glutamic acid-aspartate transporter, and glucose transporter;
• an expression product of the negative regulatory gene comprises one or more polypeptides selected from the group consisting of Succinyl-CoA synthase and Malic acid-alpha ketoglutarate transporter;
• and
• the dibasic organic acid comprises malic acid, succinic acid, or fumaric acid.