Cardiotonic steroid antagonists and related methods
AssigneeMarshall University Research Corporation
InventorsZijian Xie, Moumita Banerjee
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Abstract
Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.
Claims18
A non-naturally occurring peptide, consisting of the sequence of SEQ ID NO:
- 1 operably linked to a cell penetrating peptide.
A vector, consisting of a nucleic acid encoding a non-naturally occurring peptide having the sequence of SEQ ID NO:
- 1 operably linked to an expression cassette.
A composition, comprising a non-naturally occurring peptide and a pharmaceutically-acceptable vehicle, carrier, or excipient, the non-naturally occurring peptide consisting of the sequence of SEQ ID NO:
- 1 operably linked to a cell penetrating peptide.
A method of treating a Src-associated disease, comprising administering an effective amount of a non-naturally occurring peptide consisting of the sequence of SEQ ID NO:
- 1 to a subject in need thereof.
A method for reducing Src activity in a cell, comprising contacting a cell with an effective amount of a peptide consisting of the sequence of SEQ ID NO:
- 1 operably linked to a cell penetrating peptide.
Dependencies are inferred from the claim text.