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AssigneesErasmus University Medical Center Rotterdam, Dr. Soliman Fakeeh Hospital
InventorsBartholomeus Leonardus Haagmans, Theodorus Marinus Bestebroer, Sander van Boheemen, Ronaldus Adrianus Maria Fouchier, Albertus Dominicus Marcellinus Erasmus Osterhaus, Ali Moh Zaki, Victor Stalin Raj, Berend Jan Bosch
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The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus classifiable as belonging to the Order: Nidovirales; Family: Coronaviridae; Subfamily: Coronavirinae; Genus: Betacoronavirus; and non-Lineage A, non-Lineage B or non-Lineage D, human betacoronavirus. The invention also provides a human virus having a receptor binding domain (RBD) capable of binding to a dipeptidyl peptidase 4. The invention also provides diagnostic means and methods, prophylactic means and methods and therapeutic means and methods to be employed in the diagnosis, prevention and/or treatment of disease, in particular of respiratory disease, in particular of mammals, more in particular in humans.
A diagnostic kit for diagnosing a MERS-CoV infection comprising:
A proteinaceous substance comprising a proteinaceous molecule encoded by a nucleic acid molecule at least 95% identical to the sequence of SEQ ID NO:
Dependencies are inferred from the claim text.