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US 10,780,199 B2Granted
Methods of applying a hydrophilic coating to a substrate, and substrates having a hydrophilic coating
AssigneeHollister Incorporated
InventorThomas H. Gilman
Life of this patent
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Abstract
This invention relates to methods of applying to a substrate a hydrophilic coating that becomes lubricious when activated with water or water vapor, and to substrates having such a hydrophilic coating.
Claims21
A method of applying a hydrophilic coating on an uncoated surface of a catheter tube, the method comprising:
- contacting said uncoated surface of the catheter tube with a solution, the uncoated surface comprising a blend of a water-swellable polymer and a separate non-water-swellable polymer, wherein the solution swells water swellable polymer, the solution comprising water and at least one of (i) a water-soluble polymer capable of being cross-linked to form a cross-linked, lubricious, hydrophilic coating and (ii) a water-soluble monomer capable of being polymerized to form a cross-linked, lubricious, hydrophilic coating, and
- forming the cross-linked, lubricious, hydrophilic coating on the surface of the catheter tube.
A method of applying a hydrophilic coating on an uncoated surface of a catheter tube, the method comprising:
- contacting the uncoated surface of the catheter tube with a solution, the uncoated surface comprising a blend of a water-swellable polymer and a separate non-water-swellable polymer, wherein the solution swells the water-swellable polymer, the solution comprising water and a water-soluble polymer capable of being cross-linked to form a cross-linked, lubricious hydrophilic coating, wherein the polymer becomes entangled with the water-swellable polymer of the surface of the catheter tube;
- and
- cross-linking the water-soluble polymer, whereby the crosslinked water-soluble polymer and the water-swellable polymer of the surface of the catheter tube become linked together mechanically on a molecular scale to form a lubricious, hydrophilic coating securely anchored to the surface of the catheter tube.
A method of attaching a hydrophilic coating on an uncoated surface of a catheter tube, the method comprising:
- contacting the uncoated surface of the catheter tube with a solution, the uncoated surface comprising a blend of a water-swellable polymer and a separate non-water-swellable polymer, wherein the solution swells the water-swellable polymer, the solution comprising water and a water-soluble monomer capable of being polymerized to form a water soluble polymer, the monomer becoming dispersed within the water-swellable polymer of the surface of the catheter tube;
- polymerizing the monomer to form the water soluble polymer;
- and
- cross-linking the water-soluble polymer, whereby the crosslinked water-soluble polymer and the water-swellable polymer of the surface of the catheter tube become linked together mechanically on a molecular scale, to form a lubricious, hydrophilic coating securely anchored to the surface of the catheter tube.
1 more element
Dependencies are inferred from the claim text.