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US 10,780,174 B2Granted
Lipid-linked prodrugs
AssigneeThe University of British Columbia
InventorsMarco A. Ciufolini, Pieter R. Cullis, Yuen Yi Tam, Joshua Zaifman
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Abstract
This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.
Claims16
A compound, the compound having the structure of Formula III:
- wherein:
- A-Z is dexamethasone, wherein Z is an electronegative atom selected from N or O, such that the dexamethasone is represented by the formula A-Z—H when Z has lost an H to covalently bind to Y;
- Y is CH2 or C(═O);
- T5 is 0-6 carbon atoms;
- and
- L4 is C9-C29 linear or branched carbon chain, having one or more, cis or trans C═C double bonds and optionally substituted with OH or has the Formula V:
- wherein,
- T2 is 1-4 carbon atoms;
- T3 is 0-4 carbon atoms;
- T4 is 0-4 carbon atoms;
- J1 is —O—C(═O)-L1;
- J2 is —COOH, —OH, —NH2, —SH, —NMe2, or —NHMe;
- and
- L1 is C9-C29 linear or branched carbon chain, optionally having one or more, cis or trans C═C double bonds and optionally substituted with OH.
11 more elements
Dependencies are inferred from the claim text.