Compositions for the treatment of intestinal disorders
AssigneeDevintec Sagl
InventorsMiguel Angel Alonso Cohen, Marco Di Fulvio
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AssigneeDevintec Sagl
InventorsMiguel Angel Alonso Cohen, Marco Di Fulvio
Estimating the term…
The invention provides a process for preparing a protein-polysaccharide conjugated product comprising: (a) preparing a mixture comprising pea protein, polysaccharide, and an appropriate polar solvent; wherein: the weight ratio between polysaccharide and protein is comprised from 20:80 to 60:40, and the pH of the solution is comprised from 8.0 to 10.5; and performing a Maillard reaction by heating the solution resulting from step (a) at an appropriate temperature for the necessary period of time to conjugate the protein and the polysaccharide. The invention further provides a conjugated product obtainable by the process of the invention, as well as pharmaceutical compositions comprising the conjugate and to their use in the treatment in gastrointestinal disorders. The conjugate of the invention shows a remarkable improvement in preventing and/or treating intestinal diseases, such as mucositis.
A method for the prevention and/or treatment of gastrointestinal disorders in a subject, the method comprising administering a therapeutically effective amount of a pea protein xyloglucan conjugated product to a subject in need thereof,
A method for the prevention and/or treatment of an intestinal mucosa inflammatory disorder caused by an anti-cancer treatment in a subject, the method comprising administering a therapeutically effective amount of a combination therapy comprising a pea protein-xyloglucan conjugated product with the anti-cancer treatment to a subject in need thereof,
Dependencies are inferred from the claim text.