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AssigneeKM Biologics Co., Ltd.
InventorsHiroshi Nakatake, Masaki Hirashima, Hideki Takeo, Reiko Matsuyama, Wataru Morikawa
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A method for monomerization of MMP-7 aggregates is provided. A method for monomerization of MMP-7 aggregates which comprises treating MMP-7 aggregates with a buffer solution comprising a monovalent cation chloride (sodium chloride, potassium chloride, etc.) at a low concentration or with a buffer solution not comprising a monovalent cation chloride, a process for preparing MMP-7 which involves said method for monomerization, and a (pharmaceutical) composition comprising MMP-7 in the aforementioned buffer solution. In case that a (pharmaceutical) composition comprising MMP-7 at a low concentration is prepared, the aforementioned buffer solution comprising sugar alcohols or sugars is used.
A method for monomerization of matrix metalloproteinase 7 (MMP-7) aggregates which comprises treating MMP-7 aggregates with a solution comprising a monovalent cation compound at 80 mM or less or with a solution not comprising a monovalent cation compound, wherein MMP-7 monomers are obtained.
A process for preparing monomers of MMP-7 comprising the following steps:
Dependencies are inferred from the claim text.