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US 10,774,047 B2Granted
Dimeric quinacrine derivatives as autophagy inhibitors for cancer therapy
AssigneeThe Trustees of the University of Pennsylvania
InventorsRavi K. Amaravadi, Jeffrey Winkler
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Abstract
The invention provides dimeric quinacrine derivatives and related compounds and compositions, methods of treatment and syntheses. The novel compounds exhibit unexpected anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.
Claims4
A compound having a chemical structure which is:
- or
- a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.