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US 10,772,987 B2Granted
Mineral coated scaffolds
AssigneeTRS Holdings LLC
InventorsLeenaporn Jongpaiboonkit, William L. Murphy
Life of this patent
Estimating the term…
Abstract
Provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase.
Claims29
A method for producing a mineral coated scaffold comprising:
- contacting a scaffold comprising a matrix material and a modified simulated body fluid, wherein the modified simulated body fluid comprises 20 mM Tris, at least 5 mM CaCl2 and at least 2 mM KH2PO4;
- and
- incubating the scaffold and the modified simulated body fluid for a period of time under conditions sufficient to form a mineral coated scaffold,
- wherein the modified simulated body fluid is adjusted to a pH of about 6.5 to about 7.2,
- wherein the mineral coating comprises a carbonate-substituted, calcium-deficient hydroxyapatite component, and the mineral coating has a plate-like nanostructure and a porosity between about 20% and about 28%.
2 more elements
A mineral coated scaffold comprising a matrix material, wherein the mineral coating comprises a carbonate-substituted, calcium-deficient hydroxyapatite component;
- and wherein the mineral coating formed from an incubated simulated body fluid comprising 5 mM CaCl2 and about 2 mM KH2PO4 and the mineral coating comprises a porosity between about 20% and about 28% and a plate-like nanostructure.
A method, comprising:
- functionalizing a surface of a scaffold, wherein the scaffold comprises a matrix material;
- contacting the scaffold with a modified simulated body fluid, wherein the modified simulated body fluid comprises 20 mM Tris, at least 5 mM CaCl2 and at least 2 mM KH2PO4;
- and
- incubating the scaffold and the modified simulated body fluid for a period of time under conditions sufficient to form a mineral coated scaffold, wherein the mineral coating comprises a carbonate-substituted, calcium-deficient hydroxyapatite component, and the mineral coating has a plate-like nanostructure and a porosity between about 20% and about 28% and the modified simulated body fluid is at a pH of 6.5 to 7.2.
1 more element
A method, comprising:
- hydrolyzing a scaffold;
- contacting the scaffold comprising a matrix material and a modified simulated body fluid,
- wherein the modified simulated body fluid comprises 20 mM Tris, at least 5 mM CaCl2 and at least 2 mM KH2PO4;
- and
- incubating the scaffold and the modified simulated body fluid for a period of time under conditions sufficient to form a mineral coated scaffold, the modified simulated body fluid being at a pH of 6.5 to 7.2,
- wherein the mineral coating comprises a carbonate-substituted, calcium-deficient hydroxyapatite component, and the mineral coating has a plate-like nanostructure and a porosity between about 20% and about 28%.
3 more elements
Dependencies are inferred from the claim text.