Fragments of P97 and uses thereof
AssigneeBioasis Technologies, Inc.
InventorsTimothy Z. Vitalis, Reinhard Gabathuler
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Abstract
Provided are fragments of human p97 (melanotransferrin) polypeptides having blood-brain barrier (BBB) transport activity, including variants and combinations thereof, conjugates comprising the p97 fragments, and related methods of use thereof, for instance, to facilitate delivery of therapeutic or diagnostic agents across the BBB.
Claims15
A method for facilitating the transport of therapeutic agents across the blood brain barrier (BBB) comprising administering to a subject in need thereof, a pharmaceutical composition comprising a p97 fragment that is conjugated to a therapeutic agent optionally via a linker, to form a p97-agent conjugate, wherein the p97 fragment consists essentially of DSSHAFTLDELR (SEQ ID NO:
- 13).
Dependencies are inferred from the claim text.