Modulation and detection of a neuronal alternative splicing regulatory network for treatment and diagnosis of neurological disorders
AssigneesThe Governing Council of the University of Toronto, Sinai Health System
InventorsBenjamin J. Blencowe, Mathieu Quesnel-Vallieres, Manuel Irimia, Bushra Raj, Sabine P. Cordes
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Abstract
Methods for treatment and diagnosis of neurological disorders such as autism and autism spectrum disorder are disclosed. Also disclosed are modulators of alternative splicing regulators SRRM4 and/or SRRM3 for treating neurological disorders. Further disclosed are agents that modulate the expression of at least one splice variant for treating neurological disorders. Mouse models of neurological disorders having increased or decreased expression of SRRM4 and/or SRRM3 are also disclosed.
Claims5
A method of increasing neurite outgrowth or increasing neuron survival in a population of cortical neurons comprising administering MG132 to a subject in need thereof.
Dependencies are inferred from the claim text.