Back to results
US 10,772,913 B2Granted
Administration of kynurenine depleting enzymes for tumor therapy
AssigneeBoard of Regents, The University of Texas System
InventorsGeorge Georgiou, Everett Stone
Life of this patent
Estimating the term…
Abstract
Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
Claims19
An isolated polypeptide comprising a kynureninase enzyme having an amino acid sequence that is at least 90% identical to SEQ ID NO:
- 8, and having one or more substitutions relative to SEQ ID NO:
- 8, wherein the one or more substitutions comprise a substitution of the Phe found at position 306 of SEQ ID NO:
- 8, wherein the enzyme is formulated in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.