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US 10,772,905 B2Granted
Methods and compositions for the activation of gamma-delta T-cells
AssigneeAmerican Gene Technologies International Inc.
InventorsCharles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
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Abstract
The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
Claims14
A method of treating a cancer in a subject using an immunotherapy-based composition, the method comprising:
- administering a therapeutically-effective amount of a bisphosphonate drug to the subject;
- and
- administering a therapeutically-effective amount of the immunotherapy-based composition to the subject,
- wherein the immunotherapy-based composition comprises a lentiviral particle, the lentiviral particle comprising:
- an envelope protein capable of infecting one or more target cells, and
- at least one encoded shRNA capable of inhibiting production of farnesyl diphosphate synthase, or
- at least one encoded microRNA capable of inhibiting production of farnesyl diphosphate synthase.
4 more elements
Dependencies are inferred from the claim text.