# US 10,770,271 B2 · Plasma-activated saline solutions and method of making plasma activated saline solutions

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- Number: US 10,770,271 B2
- Document ID: US10770271B2
- Status: Granted
- Kind: B2
- Application number: 16/298,484
- Filed: 2019-03-11
- Published: 2019-09-12
- Granted: 2020-09-08
- Earliest claimed: 2018-03-09
- Assignees: US Patent Innovations, LLC
- Applicants: U.S. Patent Innovations LLC
- Inventors: Jerome Canady; Michael Keidar; Zhitong Chen
- Web page: https://patentgrep.com/patent/US10770271B2

## CPC

- H01J 37/32825: {Working under atmospheric pressure or higher}
- A61K 35/08: Mineral waters; Sea water
- H01J 37/32366: {Localised processing}
- H01J 37/32422: {Arrangement for selecting ions or species in the plasma}
- H01J 37/32568: {Relative arrangement or disposition of electrodes; moving means}
- A61P 35/00: Antineoplastic agents
- H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method for manufacturing plasma-activated saline for treatment of cancer cells. The method comprises the steps of immersing a cathode in saline solution in a container, positioning an anode at a fixed distance from a surface of said saline solution in said container and applying electrical energy to said anode for a fixed period of time, wherein said fixed distance and said fixed period of time are selected to cause a plasma self-organized pattern at a surface of said saline solution with an atmospheric discharge between said anode and said cathode.

## Claims

### Claim 1

A method for manufacturing plasma-activated saline for treatment of cancer cells comprising:
immersing a cathode in saline solution in a container;
positioning an anode at a fixed distance from a surface of said saline solution in said container; and
applying electrical energy to said anode for a fixed period of time;
wherein said fixed distance and said fixed period of time are selected to cause a plasma self-organized pattern at a surface of said saline solution with an atmospheric discharge between said anode and said cathode and
where in said plasma self-organized pattern comprises a double ring structure.

### Claim 2 (depends on 1)

The method for manufacturing plasma-activated saline for treatment of cancer cells according to claim 1 wherein said fixed distance is 4-6 mm.

### Claim 3 (depends on 1)

The method for manufacturing plasma-activated saline for treatment of cancer cells according to claim 1 wherein said fixed time is 40 seconds.

### Claim 4 (depends on 1)

The method for manufacturing plasma-activated saline for treatment of cancer cells according to claim 1 wherein said double ring structure comprises a solid inner ring surrounded by a continuous outer ring.

### Claim 5 (depends on 1)

The method for manufacturing plasma-activated saline for treatment of cancer cells according to claim 1 wherein said double ring structure comprises a solid inner ring surrounded by a discontinuous outer ring.

### Claim 6 (depends on 1)

The method for manufacturing plasma-activated saline for treatment of cancer cells according to claim 1 wherein said double ring structure comprises a continuous inner ring surrounded by a continuous outer ring.

### Claim 7 (depends on 1)

The method for manufacturing plasma-activated saline for treatment of cancer cells according to claim 1 wherein said double ring structure comprises a continuous inner ring surrounded by a discontinuous outer ring.