# US 10,768,253 B2 · MR imaging with signal suppression of a spin series

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- Number: US 10,768,253 B2
- Document ID: US10768253B2
- Status: Granted
- Kind: B2
- Application number: 16/002,467
- Filed: 2018-06-07
- Published: 2018-12-06
- Granted: 2020-09-08
- Earliest claimed: 2014-08-12
- Assignees: Siemens Healthcare GmbH
- Applicants: Siemens Aktiengesellschaft
- Inventors: Thorsten Feiweier
- Web page: https://patentgrep.com/patent/US10768253B2

## CPC

- G01R 33/4833: {using spatially selective excitation of the volume of interest, e.g. selecting non-orthogonal or inclined slices}
- A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
- G01R 33/50: based on the determination of relaxation times {, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences}
- G01R 33/543: {Control of the operation of the MR system, e.g. setting of acquisition parameters prior to or during MR data acquisition, dynamic shimming, use of one or more scout images for scan plane prescription (G01R33/546 takes precedence)}
- G01R 33/5607: {by reducing the NMR signal of a particular spin species, e.g. of a chemical species for fat suppression, or of a moving spin species for black-blood imaging}
- G01R 33/561: by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
- G01R 33/5602: {by filtering or weighting based on different relaxation times within the sample, e.g. T1 weighting using an inversion pulse}
- G01R 33/56527: {due to chemical shift effects}
- G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

In a magnetic resonance measurement sequence, an inversion pulse is applied that acts on a longitudinal magnetization of a first spin species and a second spin species, for example on a water portion and a fat portion. An excitation pulse is applied after a predetermined time period. At least one manipulation pulse is subsequently applied, respectively with associated gradient pulse.

## Claims

### Claim 1

A method to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said method comprising:
operating a magnetic resonance apparatus with the examination subject situated therein, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, operating said magnetic resonance apparatus to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
after applying said excitation pulse and said associated first gradient pulse, operating said magnetic resonance apparatus to apply at least one manipulation pulse and an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, said second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
operating said magnetic resonance apparatus to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
operating said magnetic resonance apparatus to suppress signals from said second spin species in the acquired magnetic resonance data by, in a partial region of said slice, applying said inversion pulse with different flip angles for said first spin species and said second spin species due to said frequency shift, and applying said excitation pulse with a disappearing flip angle for said second spin species; and
processing the acquired magnetic resonance data in a computerized processor to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and making said electronic signal available at an output of said processor.

### Claim 2 (depends on 1)

A method as claimed in claim 1, comprising:
operating said magnetic resonance apparatus to apply said excitation pulse with a spatial domain profile of the flip angle thereof having an edge width that is smaller than an edge width of a spatial domain profile of the flip angle of said at least one manipulation pulse.

### Claim 3 (depends on 1)

A method as claimed in claim 1, comprising:
operating said magnetic resonance apparatus to apply said excitation pulse to excite transverse magnetization in a slice thickness of said slice with a finite flip angle, said slice thickness being smaller than a slice thickness in which said at least one manipulation pulse refocuses the transverse magnetization with a finite flip angle.

### Claim 4 (depends on 1)

A method as claimed in claim 1, comprising:
operating said magnetic resonance apparatus to apply said excitation pulse to excite transverse magnetization in a slice thickness of said slice with a finite flip angle, said slice thickness being approximately equal to a total width of said slice.

### Claim 5 (depends on 1)

A method as claimed in claim 1, comprising
operating said magnetic resonance apparatus to apply said at least one manipulation pulse to refocus the transverse magnetization in a slice thickness of said examination subject with a finite flip angle, said slice thickness being larger by a factor of 1.5 or by a factor of 2 than a total width of said slice.

### Claim 6

A method to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said method comprising:
operating a magnetic resonance apparatus with the examination subject situated therein, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, operating said magnetic resonance apparatus to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
after applying said excitation pulse and said associated first gradient pulse, operating said magnetic resonance apparatus to apply at least one manipulation pulse and an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, said second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
operating said magnetic resonance apparatus to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
operating said magnetic resonance apparatus to suppress signals from said second spin species in the acquired magnetic resonance data by applying said inversion pulse with a spatial domain profile of a flip angle thereof for said first spin species that is asymmetrical relative to a middle of said slice; and
processing the acquired magnetic resonance data in a computerized processor to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and making said electronic signal available at an output of said processor.

### Claim 7 (depends on 6)

A method as claimed in claim 6 comprising:
operating said magnetic resonance apparatus to apply said inversion pulse with said spatial domain profile of said flip angle having a greater extent opposite to a direction of said frequency shift of said second spin species relative to said first spin species, than along said direction of said frequency shift of said second spin species relative to said first spin species.

### Claim 8

A method to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said method comprising:
operating a magnetic resonance apparatus with the examination subject situated therein, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, operating said magnetic resonance apparatus to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
after applying said excitation pulse and said associated first gradient pulse, operating said magnetic resonance apparatus to apply at least two manipulation pulses each with an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, each second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
operating said magnetic resonance apparatus to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
operating said magnetic resonance apparatus to suppress signals from said second spin species in the acquired magnetic resonance data by applying said inversion pulse with a spatial domain profile of a flip angle thereof for said second spin species that, in an edge region of said slice, has an edge or a disappearing flip angle, and applying said excitation pulse with finite flip angles for said second spin species, and applying at least one of said at least two manipulation pulses, and said excitation pulse, with a spatial domain profile of the respective flip angles thereof having an edge; and
processing the acquired magnetic resonance data in a computerized processor to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and making said electronic signal available at an output of said processor.

### Claim 9 (depends on 8)

A method as claimed in claim 8, comprising:
operating said magnetic resonance apparatus to apply said at least two manipulation pulses as a first manipulation pulse and a second manipulation pulse, and applying said second gradient pulse as one second gradient pulse associated with said first manipulation pulse and another second gradient pulse associated with said second manipulation pulse, and with said one second gradient pulse having an amplitude that is different from said another second gradient pulse.

### Claim 10 (depends on 9)

A method as claimed in claim 9 comprising:
operating said magnetic resonance apparatus to apply said first and second manipulation pulses to refocus the transverse magnetization in respective, substantially identical slice thicknesses of said slice with a finite flip angle.

### Claim 11 (depends on 10)

A method as claimed in claim 10 comprising operating said magnetic resonance apparatus to apply said excitation pulse with a disappearing flip angle in said edge region.

### Claim 12

A method to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said method comprising:
operating a magnetic resonance apparatus with in which the examination subject situated therein, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, operating said magnetic resonance apparatus to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
after applying said excitation pulse and said associated first gradient pulse, operating said magnetic resonance apparatus to apply at least one manipulation pulse and an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, said second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
operating said magnetic resonance apparatus to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
operating said magnetic resonance apparatus to suppress signals from said second spin species in the acquired magnetic resonance data by applying said inversion pulse with a spatial domain profile of the flip angle thereof for said seconds spin species that, in an edge region of said slice, has an edge or a disappearing flip angle, and applying said excitation pulse with a disappearing flip angle for said second spin species; and
processing the acquired magnetic resonance data in a computerized processor to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and making said electronic signal available at an output of said processor.

### Claim 13 (depends on 12)

A method as claimed in claim 12, comprising:
operating said magnetic resonance apparatus to apply said excitation pulse with a spatial domain profile of the flip angle thereof having an edge width that is smaller than an edge width of a spatial domain profile of the flip angle of said at least one manipulation pulse.

### Claim 14 (depends on 12)

A method as claimed in claim 12, comprising:
operating said magnetic resonance apparatus to apply said excitation pulse to excite transverse magnetization in a slice thickness of said slice with a finite flip angle, said slice thickness being smaller than a slice thickness in which said at least one manipulation pulse refocuses the transverse magnetization with a finite flip angle.

### Claim 15 (depends on 12)

A method as claimed in claim 12, comprising:
operating said magnetic resonance apparatus to apply said excitation pulse to excite transverse magnetization in a slice thickness of said slice with a finite flip angle, said slice thickness being approximately equal to a total width of said slice.

### Claim 16 (depends on 12)

A method as claimed in claim 12, comprising
operating said magnetic resonance apparatus to apply said at least one manipulation pulse to refocus the transverse magnetization in a slice thickness of said examination subject with a finite flip angle, said slice thickness being larger by a factor of 1.5 or by a factor of 2 than a total width of said slice.

### Claim 17

A method to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said method comprising:
operating a magnetic resonance apparatus with the examination subject situated therein, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, operating said magnetic resonance apparatus to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
after applying said excitation pulse and said associated first gradient pulse, operating said magnetic resonance apparatus to apply at least one manipulation pulse and an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, said second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
operating said magnetic resonance apparatus to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
operating said magnetic resonance apparatus to suppress signals from said second spin species in the acquired magnetic resonance data by applying said inversion pulse with a spatial domain profile of the flip angle thereof for said second spin species that has a maximized flip angle in a region in which said excitation pulse has finite flip angles for said second spin species, and applying said inversion pulse with a spatial domain profile of the flip angle thereof for said first spin species that is asymmetrical relative to a middle of said slice; and
processing the acquired magnetic resonance data in a computerized processor to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and making said electronic signal available at an output of said processor.

### Claim 18 (depends on 17)

A method as claimed in claim 17 comprising:
operating said magnetic resonance apparatus to apply said inversion pulse with said spatial domain profile of said flip angle having a greater extent opposite to a direction of said frequency shift of said second spin species relative to said first spin species, than along said direction of said frequency shift of said second spin species relative to said first spin species.

### Claim 19

A magnetic resonance apparatus configured to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said apparatus comprising:
a magnetic resonance data acquisition unit;
a control unit configured to operate a magnetic resonance data acquisition unit, in which the examination subject is situated, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
said control unit being configured after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, to operate said magnetic resonance data acquisition unit to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
said control unit being configured after applying said excitation pulse and said associated first gradient pulse, to operate said magnetic resonance data acquisition unit to apply at least one manipulation pulse and an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, said second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
said control unit being configured to operate said magnetic resonance data acquisition unit to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
said control unit being configured to operate said magnetic resonance data acquisition unit to suppress signals from said second spin species in the acquired magnetic resonance data by, applying said inversion pulse in a partial region of said slice with different flip angles for said first spin species and said second spin species due to said frequency shift, and applying said excitation pulse with a disappearing flip angle for said second spin species; and
a computerized processor configured to process the acquired magnetic resonance data to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and to make said electronic signal available at an output of said processor.

### Claim 20

A magnetic resonance apparatus configured to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said apparatus comprising:
a magnetic resonance data acquisition unit;
a control unit configured to operate said magnetic resonance data acquisition unit with the examination subject situated therein, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
said control unit being configured after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, to operate said magnetic resonance data acquisition unit to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
said control unit being configured after applying said excitation pulse and said associated first gradient pulse, to operate said magnetic resonance data acquisition unit to apply at least one manipulation pulse and an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, said second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
said control unit being configured to operate said magnetic resonance data acquisition unit to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
said control unit being configured to operate said magnetic resonance data acquisition unit to suppress signals from said second spin species in the acquired magnetic resonance data by, applying said inversion pulse with a spatial domain profile of a flip angle thereof for said first spin species that is asymmetrical relative to a middle of said slice; and
a computerized processor configured to process the acquired magnetic resonance data to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and to make said electronic signal available at an output of said processor.

### Claim 21

A magnetic resonance data apparatus configured to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said apparatus comprising:
a magnetic resonance data acquisition unit;
a control unit configured to operate said magnetic resonance data acquisition unit with the examination subject situated therein, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
said control unit being configured after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, to operate said magnetic resonance data acquisition unit to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
said control unit being configured after applying said excitation pulse and said associated first gradient pulse, to operate said magnetic resonance data acquisition unit to apply at least two manipulation pulses each with an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, each second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
said control unit being configured to operate said magnetic resonance data acquisition unit to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
said control unit being configured to operate said magnetic resonance data acquisition unit to suppress signals from said second spin species in the acquired magnetic resonance data by applying said inversion pulse with a spatial domain profile of a flip angle thereof for said second spin species that, in an edge region of said slice, has an edge or a disappearing flip angle, and applying said excitation pulse with finite flip angles for said second spin species, and applying at least one of said at least two manipulation pulses, and said excitation pulse, with a spatial domain profile of the respective flip angles thereof having an edge; and
a computerized processor configured to process the acquired magnetic resonance data to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and to make said electronic signal available at an output of said processor.

### Claim 22

A magnetic resonance apparatus configured to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said apparatus comprising:
a magnetic resonance data acquisition unit;
a control unit configured to operate said magnetic resonance data acquisition unit with the examination subject situated therein, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
said control unit being configured after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, to operate said magnetic resonance data acquisition unit to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
said control unit being configured after applying said excitation pulse and said associated first gradient pulse, to operate said magnetic resonance data acquisition unit to apply at least one manipulation pulse and an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, said second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
said control unit being configured to operate said magnetic resonance data acquisition unit to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
said control unit being configured to operate said magnetic resonance data acquisition unit to suppress signals from said second spin species in the acquired magnetic resonance data by, applying said inversion pulse with a spatial domain profile of the flip angle thereof for said second spin species that, in an edge region of said slice, has an edge or a disappearing flip angle, and applying said excitation pulse with a disappearing flip angle for said second spin species; and
a computerized processor configured to process the acquired magnetic resonance data to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and to make said electronic signal available at an output of said processor.

### Claim 23

A magnetic resonance apparatus configured to acquire magnetic resonance data from nuclear spins in a slice of an examination subject, said slice comprising nuclear spins of a first spin species and a second spin species exhibiting a frequency shift relative to each other and having respectively different spin-lattice relaxation times, said apparatus comprising:
a magnetic resonance data acquisition unit;
a control unit configured to operate said magnetic resonance data acquisition unit with the examination subject situated therein, to apply an inversion pulse that acts on a longitudinal magnetization of said first spin species in said slice and on a longitudinal magnetization of said second spin species in said slice;
said control unit being configured after a predetermined time period that is dependent on said spin-lattice relaxation time of said second spin species, to operate said magnetic resonance data acquisition unit to apply an excitation pulse and an associated first gradient pulse, that produce a transverse magnetization of said nuclear spins in said slice;
said control unit being configured after applying said excitation pulse and said associated first gradient pulse, to operate said magnetic resonance data acquisition unit to apply at least one manipulation pulse and an associated second gradient pulse, that produce at least one echo of said transverse magnetization of at least said first spin species, said second gradient pulse having an amplitude that is different from an amplitude of said first gradient pulse;
said control unit being configured to operate said magnetic resonance data acquisition unit to acquire magnetic resonance data from an entirety of said slice during said at least one echo;
said control unit being configured to operate said magnetic resonance data acquisition unit to suppress signals from said second spin species in the acquired magnetic resonance data by, applying said inversion pulse with a spatial domain profile of the flip angle thereof for said second spin species that has a maximized flip angle in a region in which said excitation pulse has finite flip angles for said second spin species, and applying said inversion pulse with a spatial domain profile of the flip angle thereof for said first spin species that is asymmetrical relative to a middle of said slice; and
a computerized processor configured to process the acquired magnetic resonance data to generate an electronic signal having a format from which a magnetic resonance image of said slice can be generated, said magnetic resonance image comprising substantially only signal contributions that originate from said first spin species, and to make said electronic signal available at an output of said processor.