# US 10,768,168 B2 · Methods for identifying arthropod repellents and attractants, and compounds and compositions identified by such methods

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- Number: US 10,768,168 B2
- Document ID: US10768168B2
- Status: Granted
- Kind: B2
- Application number: 15/851,130
- Filed: 2017-12-21
- Published: 2018-07-05
- Granted: 2020-09-08
- Earliest claimed: 2013-03-15
- Assignees: The Regents of the University of California
- Applicants: The Regents of the University of California
- Inventors: Anandasankar Ray; Sean Michael Boyle; Dyan MacWilliam; Genevieve Mitchell Tauxe
- Web page: https://patentgrep.com/patent/US10768168B2

## CPC

- G01N 33/5058: {Neurological cells}
- A01N 31/02: Acyclic compounds
- A01N 31/06: Oxygen or sulfur directly attached to a cycloaliphatic ring system
- A01N 33/04: Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
- A01N 35/02: containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
- A01N 35/06: containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
- A01N 35/08: at least one of the bonds to hetero atoms is to nitrogen
- A01N 37/02: Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
- A01N 37/42: containing within the same carbon skeleton a carboxylic group or a thio analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
- A01N 41/10: Sulfones; Sulfoxides
- A01N 43/08: with oxygen as the ring hetero atom
- A01N 43/10: with sulfur as the ring hetero atom
- A01N 43/36: five-membered rings
- G01N 33/5032: {on intercellular interactions}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS

## Abstract

Provided herein are screening methods for identifying compounds for use as an arthropod repellent based on the masking or inhibition of the detection of the skin odor by a cpA neuron. Provided herein are also screening methods for identifying compounds for use as an arthropod attractant based on activation of the cpA neuron. Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds.

## Claims

### Claim 1

A method of attracting an arthropod comprising exposing the arthropod to a composition comprising 1H-pyrrole or 2-methyloxolane, or any combination thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein the arthropod is a mosquito.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition is formulated into a lotion, a cream, a spray, a dust, a vaporizer, a treated mat, a treated outerwear, an oil, a candle, or a wicked apparatus.

### Claim 4 (depends on 1)

The method of claim 1, comprising exposing the arthropod to a composition comprising 1H-pyrrole.

### Claim 5 (depends on 1)

The method of claim 1, comprising exposing the arthropod to a composition comprising 2-methyloxolane.

### Claim 6 (depends on 1)

The method of claim 1, comprising exposing the arthropod to a composition comprising 1H-pyrrole and butan-2-ol.

### Claim 7 (depends on 1)

The method of claim 1, comprising exposing the arthropod to a composition comprising 1H-pyrrole and 2-methyloxolane.

### Claim 8 (depends on 1)

The method of claim 1, comprising exposing the arthropod to a composition comprising butan-2-ol and 2-methyloxolane.

### Claim 9 (depends on 1)

The method of claim 1, comprising exposing the arthropod to a composition comprising 1H-pyrrole, butan-2-ol, and 2-methyloxolane.

### Claim 10 (depends on 2)

The method of claim 2, comprising exposing the mosquito to a composition comprising 1H-pyrrole.

### Claim 11 (depends on 2)

The method of claim 2, comprising exposing the mosquito to a composition comprising 2-methyloxolane.

### Claim 12 (depends on 2)

The method of claim 2, comprising exposing the mosquito to a composition comprising 1H-pyrrole and butan-2-ol.

### Claim 13 (depends on 2)

The method of claim 2, comprising exposing the mosquito to a composition comprising 1H-pyrrole and 2-methyloxolane.

### Claim 14 (depends on 2)

The method of claim 2, comprising exposing the mosquito to a composition comprising butan-2-ol and 2-methyloxolane.

### Claim 15 (depends on 2)

The method of claim 2, comprising exposing the mosquito to a composition comprising 1H-pyrrole, butan-2-ol, and 2-methyloxolane.

### Claim 16 (depends on 2)

The method of claim 2, wherein the mosquito is A. aegypti or A. gambiae.